Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression

BACKGROUND: Mutations of the superoxide dismutase 1 (SOD1) gene are linked to amyotrophic lateral sclerosis (ALS), an invariably fatal neurological condition involving cortico-spinal degeneration. Mechanical injury can also determine spinal cord degeneration and act as a risk factor for the developm...

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Bibliographic Details
Main Authors:	Malaspina, Andrea, Jokic, Natasa, Huang, Wenlong L, Priestley, John V
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2008
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2585103/ https://ncbi.nlm.nih.gov/pubmed/18947433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-500
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Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression

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