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Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions

Cortactin is an actin-binding protein that is overexpressed in many cancers and is a substrate for both tyrosine and serine/threonine kinases. Tyrosine phosphorylation of cortactin has been observed to increase cell motility and invasion in vivo, although it has been reported to have both positive a...

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Библиографические подробности
Главные авторы: Kruchten, Anne E., Krueger, Eugene W., Wang, Yu, McNiven, Mark A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584996/
https://ncbi.nlm.nih.gov/pubmed/18768925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00238.2008
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