Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension

Portal hypertension (PHT) is a common complication of liver cirrhosis and significantly increases morbidity and mortality. Abrogation of PHT using NSAIDs has demonstrated that prostacyclin (PGI(2)), a direct downstream metabolic product of cyclooxygenase (COX) activity, is an important mediator in t...

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Detalhes bibliográficos
Main Authors: Skill, N. J., Theodorakis, N. G., Wang, Y. N., Wu, J. M., Redmond, E. M., Sitzmann, J. V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584826/
https://ncbi.nlm.nih.gov/pubmed/18772366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00013.2008
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