Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines

Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype–phenotype relationships in human cells, including searches for QTLs influencing levels of individual mRNAs and responses to drugs and radiation. In the course of...

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Autori principali: Choy, Edwin, Yelensky, Roman, Bonakdar, Sasha, Plenge, Robert M., Saxena, Richa, De Jager, Philip L., Shaw, Stanley Y., Wolfish, Cara S., Slavik, Jacqueline M., Cotsapas, Chris, Rivas, Manuel, Dermitzakis, Emmanouil T., Cahir-McFarland, Ellen, Kieff, Elliott, Hafler, David, Daly, Mark J., Altshuler, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583954/
https://ncbi.nlm.nih.gov/pubmed/19043577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000287
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