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Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection
Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect on the molecu...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583910/ https://ncbi.nlm.nih.gov/pubmed/19043566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000281 |
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