Measles Viruses Possessing the Polymerase Protein Genes of the Edmonston Vaccine Strain Exhibit Attenuated Gene Expression and Growth in Cultured Cells and SLAM Knock-In Mice

Live attenuated vaccines against measles have been developed through adaptation of clinical isolates of measles virus (MV) in various cultured cells. Analyses using recombinant MVs with chimeric genomes between wild-type and Edmonston vaccine strains indicated that viruses possessing the polymerase...

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Main Authors: Takeda, Makoto, Ohno, Shinji, Tahara, Maino, Takeuchi, Hiroki, Shirogane, Yuta, Ohmura, Hirofumi, Nakamura, Takafumi, Yanagi, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583675/
https://ncbi.nlm.nih.gov/pubmed/18799577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00867-08
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