Cytotoxic-T-Lymphocyte-Associated Antigen 4 Blockade Abrogates Protection by Regulatory T Cells in a Mouse Model of Microbially Induced Innate Immune-Driven Colitis

Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) expressed at high levels by CD4(+) CD25(+) CD45RB(low) regulatory T cells (Treg) is essential to their homeostatic and immunoregulatory functions. However, its relevance to anti-inflammatory roles of Treg in the context of colitogenic innate immun...

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Détails bibliographiques
Auteurs principaux: Watanabe, Koichiro, Rao, Varada P., Poutahidis, Theofilos, Rickman, Barry H., Ohtani, Masahiro, Xu, Shilu, Rogers, Arlin B., Ge, Zhongming, Horwitz, Bruce H., Fujioka, Toshio, Erdman, Susan E., Fox, James G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Host Response and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583565/
https://ncbi.nlm.nih.gov/pubmed/18824539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00542-08
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