Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using Toll-like receptor 7 agonist imiquimod as vaccine adjuvant

T cell-mediated immunity to microbes and to cancer can be enhanced by the activation of dendritic cells (DCs) via Toll-like receptors (TLRs). In this study, we evaluated the safety and feasibility of topical imiquimod, a TLR7 agonist, in a series of vaccinations (26) proteins,(27) and DNA, (28, 29)...

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Detalhes bibliográficos
Main Authors: Adams, Sylvia, O'Neill, David W., Nonaka, Daisuke, Hardin, Elizabeth, Chiriboga, Luis, Siu, Kimberly, Cruz, Crystal M., Angiulli, Angelica, Angiulli, Francesca, Ritter, Erika, Holman, Rose Marie, Shapiro, Richard L., Berman, Russell S., Berner, Natalie, Shao, Yongzhao, Manches, Olivier, Pan, Linda, Venhaus, Ralph R., Hoffman, Eric W., Jungbluth, Achim, Gnjatic, Sacha, Old, Lloyd, Pavlick, Anna C., Bhardwaj, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583094/
https://ncbi.nlm.nih.gov/pubmed/18566444
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