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Targeting the UPS as therapy in multiple myeloma

The coordinated regulation of cellular protein synthesis and degradation is essential for normal cellular functioning. The ubiquitin proteasome system mediates the intracellular protein degradation that is required for normal cellular homeostasis. The 26S proteasome is a multi-enzyme protease that d...

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Detalhes bibliográficos
Main Authors: Chauhan, Dharminder, Bianchi, Giada, Anderson, Kenneth C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582802/
https://ncbi.nlm.nih.gov/pubmed/19007431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-S1-S1
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