Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle

Steric blocking peptide nucleic acid (PNA) oligonucleotides have been used increasingly for redirecting RNA splicing particularly in therapeutic applications such as Duchenne muscular dystrophy (DMD). Covalent attachment of a cell-penetrating peptide helps to improve cell delivery of PNA. We have us...

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Bibliographic Details
Main Authors: Ivanova, Gabriela D., Arzumanov, Andrey, Abes, Rachida, Yin, Haifang, Wood, Matthew J. A., Lebleu, Bernard, Gait, Michael J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582604/
https://ncbi.nlm.nih.gov/pubmed/18842625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn671
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