A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence

BACKGROUND: A non-synonymous coding polymorphism, rs16969968, of the CHRNA5 gene which encodes the alpha-5 subunit of the nicotinic acetylcholine receptor (nAChR) has been found to be associated with nicotine dependence (20). The goal of the present study is to examine the association of this varian...

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Autori principali: Grucza, Richard A, Wang, Jen C., Stitzel, Jerry A., Hinrichs, Anthony L., Saccone, Scott F., Saccone, Nancy L., Bucholz, Kathleen K., Cloninger, C. Robert, Neuman, Rosalind J., Budde, John P., Fox, Louis, Bertelsen, Sarah, Kramer, John, Hesselbrock, Victor, Tischfield, Jay, Nurnberger, John. I., Almasy, Laura, Porjesz, Bernice, Kuperman, Samuel, Schuckit, Marc A., Edenberg, Howard J., Rice, John P., Goate, Alison M., Bierut, Laura J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582594/
https://ncbi.nlm.nih.gov/pubmed/18519132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.04.018
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