Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

Obesity is a chronic, costly, and globally prevalent condition, with excess caloric intake a suspected etiologic factor. Nonsurgical treatments are modestly efficacious, and weight loss maintenance is hampered by anti-famine homeostatic mechanisms. Ghrelin, a gastric hormone linked to meal initiatio...

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Bibliographic Details
Main Authors: Mayorov, Alexander V., Amara, Neri, Chang, Jason Y., Moss, Jason A., Hixon, Mark S., Ruiz, Diana I., Meijler, Michael M., Zorrilla, Eric P., Janda, Kim D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582297/
https://ncbi.nlm.nih.gov/pubmed/18981425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711808105
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