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High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide.

Bactericidal/permeability-increasing protein (BPI) is a 55-kDa cationic protein (nBPI55) elaborated by polymorphonuclear neutrophils (PMN). BPI has potent bactericidal activity against a wide variety of gram-negative organisms and neutralizes endotoxin activities. An N-terminal fragment of nBPI55 ex...

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Udgivet i:Infect Immun
Principais autores: Gazzano-Santoro, H, Parent, J B, Grinna, L, Horwitz, A, Parsons, T, Theofan, G, Elsbach, P, Weiss, J, Conlon, P J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258228/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1398985/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.11.4754-4761.1992
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