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Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK knockout mice

While the acute inhibitory effect of opioids on locus coeruleus (LC) neurons is mediated primarily by the activation of G protein-gated inwardly-rectifying K(+) (GIRK) channels, the 3′-5′-cyclic adenosine monophosphate (cAMP)-system has been implicated in the effects of chronic morphine exposure. Pr...

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Main Authors: Torrecilla, Maria, Quillinan, Nidia, Williams, John T., Wickman, Kevin
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582177/
https://ncbi.nlm.nih.gov/pubmed/18702733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2008.06348.x
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