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The Trouble with Sliding Windows and the Selective Pressure in BRCA1

Sliding-window analysis has widely been used to uncover synonymous (silent, d(S)) and nonsynonymous (replacement, d(N)) rate variation along the protein sequence and to detect regions of a protein under selective constraint (indicated by d(N)<d(S)) or positive selection (indicated by d(N)>d(S)...

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Detalhes bibliográficos
Main Authors: Schmid, Karl, Yang, Ziheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581807/
https://ncbi.nlm.nih.gov/pubmed/19015730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003746
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