De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

The pluripotency determining gene, Oct-3/4 (also called Pou5f1) undergoes post implantation silencing in a process mediated by the histone methyltransferase (HMT) G9a. Microarray analysis now shows that this enzyme may operate as a master regulator that inactivates multiple early embryonic genes by...

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Détails bibliographiques
Auteurs principaux: Epsztejn-Litman, Silvina, Feldman, Nirit, Abu-Remaileh, Monther, Shufaro, Yoel, Gerson, Ariela, Ueda, Jun, Deplus, Rachel, Fuks, François, Shinkai, Yoichi, Cedar, Howard, Bergman, Yehudit
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581722/
https://ncbi.nlm.nih.gov/pubmed/18953337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1476
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