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Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2

T-lymphoma invasion and metastasis 1 and 2 (Tiam1 and Tiam2) are guanine nucleotide-exchange factors that specifically activate Rac GTPase by facilitating the dissociation of GDP. Translocation of Tiam1 and Tiam2 from the cytoplasm to the plasma membrane is an essential step in Rac activation and is...

詳細記述

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書誌詳細
主要な著者: Terawaki, Shin-ichi, Kitano, Ken, Hakoshima, Toshio
フォーマット: Artigo
言語:Inglês
出版事項: International Union of Crystallography 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581685/
https://ncbi.nlm.nih.gov/pubmed/18997336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108031692
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