Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate

Prostate ductal development is initiated by androgen-dependent signals in fetal urogenital sinus (UGS) mesenchyme that stimulate prostatic bud formation in UGS epithelium. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, 5 μg/kg maternal dose) inhibited ventral and dorsolateral but not anterior prostatic...

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Autori principali: Vezina, Chad M., Allgeier, Sarah Hicks, Moore, Robert W., Lin, Tien-Min, Bemis, Jeffrey C., Hardin, Heather A., Gasiewicz, Thomas A., Peterson, Richard E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
Soggetti:
Reproductive and Developmental Toxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581676/
https://ncbi.nlm.nih.gov/pubmed/18779384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn183
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