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SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5

SUMOylation is a form of post-translational modification shown to control nuclear transport. Krüppel-like factor 5 (KLF5) is an important mediator of cell proliferation and is primarily localized to the nucleus. Here we show that mouse KLF5 is SUMOylated at lysine residues 151 and 202. Mutation of t...

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Autori principali: Du, James X., Bialkowska, Agnieszka B., McConnell, Beth B., Yang, Vincent W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581587/
https://ncbi.nlm.nih.gov/pubmed/18782761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803612200
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