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Interactions of Escherichia coli Thioredoxin, the Processivity Factor, with Bacteriophage T7 DNA Polymerase and Helicase

Escherichia coli thioredoxin binds to a unique flexible loop of 71 amino acid residues, designated the thioredoxin binding domain (TBD), located in the thumb subdomain of bacteriophage T7 gene 5 DNA polymerase. The initial designation of thioredoxin as a processivity factor was premature. Rather it...

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Detalhes bibliográficos
Main Authors: Ghosh, Sharmistha, Hamdan, Samir M., Cook, Timothy E., Richardson, Charles C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581581/
https://ncbi.nlm.nih.gov/pubmed/18757858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805062200
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