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The Kinase Activity of IL-1 Receptor-associated Kinase 4 Is Required for Interleukin-1 Receptor/Toll-like Receptor-induced TAK1-dependent NFκB Activation

Two parallel interleukin-1 (IL-1)-mediated signaling pathways have been uncovered for IL-1R-TLR-mediated NFκB activation: TAK1-dependent and MEKK3-dependent pathways, respectively. The TAK1-dependent pathway leads to IKKα/β phosphorylation and IKKβ activation, resulting in classic NFκB activation th...

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Bibliografiske detaljer
Main Authors: Frączek, Jerzy, Kim, Tae Whan, Xiao, Hui, Yao, Jianhong, Wen, Qian, Li, Yali, Casanova, Jean-Laurent, Pryjma, Juliusz, Li, Xiaoxia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581573/
https://ncbi.nlm.nih.gov/pubmed/18794297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804779200
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