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Isothermal Titration Calorimetry Reveals Differential Binding Thermodynamics of Variable Region-identical Antibodies Differing in Constant Region for a Univalent Ligand

The classical view of immunoglobulin molecules posits two functional domains defined by the variable (V) and constant (C) regions, which are responsible for antigen binding and antibody effector functions, respectively. These two domains are thought to function independently. However, several lines...

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Bibliografiske detaljer
Main Authors: Dam, Tarun K., Torres, Marcela, Brewer, C. Fred, Casadevall, Arturo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581562/
https://ncbi.nlm.nih.gov/pubmed/18806257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806473200
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