NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

The leukocyte integrin, lymphocyte function-associated antigen 1 (LFA-1) (CD11a/CD18), mediates cell adhesion and signaling in inflammatory and immune responses. To support these functions, LFA-1 must convert from a resting to an activated state that avidly binds its ligands such as intercellular ad...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Huth, Jeffrey R., Olejniczak, Edward T., Mendoza, Renaldo, Liang, Heng, Harris, Edith A. S., Lupher, Mark L., Wilson, Amy E., Fesik, Stephen W., Staunton, Donald E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25811/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805782/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5231
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