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Estimating large-scale signaling networks through nested effect models with intervention effects from microarray data
Motivation: Targeted interventions using RNA interference in combination with the measurement of secondary effects with DNA microarrays can be used to computationally reverse engineer features of upstream non-transcriptional signaling cascades based on the nested structure of effects. Results: We ex...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579711/ https://ncbi.nlm.nih.gov/pubmed/18227117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btm634 |
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