Inhibition of HIF-1α by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo

In a previous study, we showed that a novel anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106, ECyd) increased the antitumour efficacy of X-irradiation. However, its effects on hypoxic cells in tumours remain unclarified. Here, we show that TAS106 enhances the induction of apo...

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Detalhes bibliográficos
Main Authors: Yasui, H, Ogura, A, Asanuma, T, Matsuda, A, Kashiwakura, I, Kuwabara, M, Inanami, O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579694/
https://ncbi.nlm.nih.gov/pubmed/18854835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604720
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