Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis

BACKGROUND: The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches, but how the microenvironment created by the initial three-dimensional (3D) growth of cancer cells affects their angiogenesis-stimulating potential is u...

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Main Authors: Valcárcel, María, Arteta, Beatriz, Jaureguibeitia, Arrate, Lopategi, Aritz, Martínez, Iñigo, Mendoza, Lorea, Muruzabal, Francisco J, Salado, Clarisa, Vidal-Vanaclocha, Fernando
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579286/
https://ncbi.nlm.nih.gov/pubmed/18844982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-57
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