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(4-Aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase

Increased expression of the serine protease urokinase-type plasminogen activator (uPA) in tumor tissues is highly correlated with tumor cell migration, invasion, proliferation, progression, and metastasis. Thus inhibition of uPA activity represents a promising target for antimetastatic therapy. So f...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sperl, Stefan, Jacob, Uwe, Arroyo de Prada, Nuria, Stürzebecher, Jörg, Wilhelm, Olaf G., Bode, Wolfram, Magdolen, Viktor, Huber, Robert, Moroder, Luis
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25790/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805774/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5113
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