Smad2 functions as a co-activator of canonical Wnt/β-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300

Both canonical Wnt/β-catenin and TGFβ/Smad signaling pathways coordinately regulate pattern formation during embryogenesis as well as tumor progression. Evidence of cross-talk between these two pathways has been reported. Here we demonstrated that the Activin-like kinase 4 (Alk4)/Smad2 pathway facil...

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Detalhes bibliográficos
Main Authors: Hirota, Morihisa, Watanabe, Kazuhide, Hamada, Shin, Sun, Youping, Strizzi, Luigi, Mancino, Mario, Nagaoka, Tadahiro, Gonzales, Monica, Seno, Masaharu, Bianco, Caterina, Salomon, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2578836/
https://ncbi.nlm.nih.gov/pubmed/18595660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.05.003
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