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Glutathione synthesis is essential for mouse development but not for cell growth in culture

Glutathione (GSH) is a major source of reducing equivalents in mammalian cells. To examine the role of GSH synthesis in development and cell growth, we generated mice deficient in GSH by a targeted disruption of the heavy subunit of γ-glutamylcysteine synthetase (γGCS-HS(tm1)), an essential enzyme i...

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Detalhes bibliográficos
Main Authors: Shi, Zheng-Zheng, Osei-Frimpong, Joseph, Kala, Geeta, Kala, Subbarao V., Barrios, Roberto J., Habib, Geetha M., Lukin, Dana J., Danney, Christopher M., Matzuk, Martin M., Lieberman, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC25788/
https://ncbi.nlm.nih.gov/pubmed/10805773
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