Glutathione synthesis is essential for mouse development but not for cell growth in culture

Glutathione (GSH) is a major source of reducing equivalents in mammalian cells. To examine the role of GSH synthesis in development and cell growth, we generated mice deficient in GSH by a targeted disruption of the heavy subunit of γ-glutamylcysteine synthetase (γGCS-HS(tm1)), an essential enzyme i...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shi, Zheng-Zheng, Osei-Frimpong, Joseph, Kala, Geeta, Kala, Subbarao V., Barrios, Roberto J., Habib, Geetha M., Lukin, Dana J., Danney, Christopher M., Matzuk, Martin M., Lieberman, Michael W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25788/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805773/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5101
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