DNA polymerase active site is highly mutable: Evolutionary consequences
DNA polymerases contain active sites that are structurally superimposable and highly conserved in sequence. To assess the significance of this preservation and to determine the mutational burden that active sites can tolerate, we randomly mutated a stretch of 13 amino acids within the polymerase cat...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2000
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805772/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5095 |
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