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Distinctive Pattern of Sequence Polymorphism in the NS3 Protein of Hepatitis C Virus Type 1b Reflects Conflicting Evolutionary Pressures
Analysis of complete polyprotein-encoding sequences of hepatitis C virus genotype 1b (HCV-1b) showed evidence not only of past purifying selection but also of abundant slightly deleterious nonsynonymous variants subject to ongoing purifying selection. The NS3 protein (with protease and NTPase/helica...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577380/ https://ncbi.nlm.nih.gov/pubmed/18632963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.2008/000992-0 |
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