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Distinctive Pattern of Sequence Polymorphism in the NS3 Protein of Hepatitis C Virus Type 1b Reflects Conflicting Evolutionary Pressures

Analysis of complete polyprotein-encoding sequences of hepatitis C virus genotype 1b (HCV-1b) showed evidence not only of past purifying selection but also of abundant slightly deleterious nonsynonymous variants subject to ongoing purifying selection. The NS3 protein (with protease and NTPase/helica...

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Bibliografiset tiedot
Päätekijät: Irausquin, Stephanie Jiménez, Hughes, Austin L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577380/
https://ncbi.nlm.nih.gov/pubmed/18632963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.2008/000992-0
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