Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor

Inhibitor of growth 1 (ING1) is implicated in oncogenesis, DNA damage repair and apoptosis. Mutations within the ING1 gene and altered expression levels of ING1 are found in multiple human cancers. Here, we show that both DNA repair and apoptotic activities of ING1 require the interaction of the C-t...

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Hauptverfasser: Peña, P. V., Hom, R. A., Hung, T., Lin, H., Kuo, A. J., Wong, R. PC., Subach, O. M., Champagne, K. S., Zhao, R., Verkhusha, V. V., Li, G., Gozani, O., Kutateladze, T. G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576750/
https://ncbi.nlm.nih.gov/pubmed/18533182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.04.061
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