Human α-Defensins Inhibit BK Virus Infection by Aggregating Virions and Blocking Binding to Host Cells

BK virus (BKV) is a polyomavirus that establishes a lifelong persistence in most humans and is a major impediment to success of kidney grafts. The function of the innate immune system in BKV infection and pathology has not been investigated. Here we examine the role of antimicrobial defensins in BKV...

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Autori principali: Dugan, Aisling S., Maginnis, Melissa S., Jordan, Joslynn A., Gasparovic, Megan L., Manley, Kate, Page, Rebecca, Williams, Geoffrey, Porter, Edith, O'Hara, Bethany A., Atwood, Walter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576552/
https://ncbi.nlm.nih.gov/pubmed/18782756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805902200
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