Role of CCL3L1-CCR5 Genotypes in the Epidemic Spread of HIV-1 and Evaluation of Vaccine Efficacy

BACKGROUND: Polymorphisms in CCR5, the major coreceptor for HIV, and CCL3L1, a potent CCR5 ligand and HIV-suppressive chemokine, are determinants of HIV-AIDS susceptibility. Here, we mathematically modeled the potential impact of these genetic factors on the epidemic spread of HIV, as well as on its...

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Main Authors: Kulkarni, Hemant, Marconi, Vincent C., Agan, Brian K., McArthur, Carole, Crawford, George, Clark, Robert A., Dolan, Matthew J., Ahuja, Sunil K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576446/
https://ncbi.nlm.nih.gov/pubmed/18989363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003671
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