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cGMP decreases surface NKCC2 levels in the thick ascending limb: role of phosphodiesterase 2 (PDE2)

NaCl absorption in the medullary thick ascending limb of the loop of Henle (THAL) is mediated by the apical Na/K/2Cl cotransporter (NKCC2). Hormones that increase cGMP, such as nitric oxide (NO) and natriuretic peptides, decrease NaCl absorption by the THAL. However, the mechanism by which cGMP decr...

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Hlavní autoři: Ares, Gustavo R., Caceres, Paulo, Alvarez-Leefmans, Francisco J., Ortiz, Pablo A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576138/
https://ncbi.nlm.nih.gov/pubmed/18684888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00449.2007
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