TGF-α increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms

Transforming growth factor-α (TGF-α) may be an important mediator of wound healing and the injury response. Human bone marrow mesenchymal stem cells (MSCs) release VEGF as a potentially beneficial paracrine response; however, it remains unknown whether TGF-α stimulates the production of VEGF from MS...

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Detalhes bibliográficos
Main Authors: Wang, Yue, Crisostomo, Paul R., Wang, Meijing, Markel, Troy A., Novotny, Nathan M., Meldrum, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Inflammation, Cytokines, Neuroimmune Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576096/
https://ncbi.nlm.nih.gov/pubmed/18685072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90383.2008
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