Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans

Oxidative stress impairs endothelium-dependent dilation (EDD) with aging in healthy sedentary adults. Increased cytochrome P-450 2C9 (CYP 2C9) signaling can contribute to oxidative stress-mediated suppression of EDD, but its role in aging is unknown. We hypothesized that inhibition of CYP 2C9 signal...

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Main Authors: Donato, Anthony J., Eskurza, Iratxe, Jablonski, Kristen L., Gano, Lindsey B., Pierce, Gary L., Seals, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576044/
https://ncbi.nlm.nih.gov/pubmed/18669935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.90629.2008
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