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Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1

Many plasma membrane proteins in yeast are ubiquitinated and endocytosed, but how they are recognized for modification has remained unknown. Here, we show that the manganese transporter Smf1 is endocytosed when cells are exposed to cadmium ions, that this endocytosis depends on Rsp5-dependent ubiqui...

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Autori principali: Nikko, Elina, Sullivan, James A, Pelham, Hugh R B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575832/
https://ncbi.nlm.nih.gov/pubmed/18953286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.199
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