TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling

Murine models of starvation-induced muscle atrophy demonstrate that reduced protein kinase B (AKT) function upregulates the atrophy-related gene atrogin-1/MAFbx (atrogin). The mechanism involves release of inhibition of Forkhead transcription factors, namely Foxo1 and Foxo3. Elevated atrogin mRNA al...

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Bibliografiska uppgifter
Huvudupphovsmän: Moylan, Jennifer S., Smith, Jeffrey D., Chambers, Melissa A., McLoughlin, Thomas J., Reid, Michael B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2008
Ämnen:
Muscle Cell Biology and Cell Motility
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575831/
https://ncbi.nlm.nih.gov/pubmed/18701653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00041.2008
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