Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

INTRODUCTION: The small leucine-rich proteoglycans (SLRPs) modulate tissue organization, cellular proliferation, matrix adhesion, growth factor and cytokine responses, and sterically protect the surface of collagen type I and II fibrils from proteolysis. Catabolism of SLRPs has important consequence...

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Main Authors: Melrose, James, Fuller, Emily S, Roughley, Peter J, Smith, Margaret M, Kerr, Briedgeen, Hughes, Clare E, Caterson, Bruce, Little, Christopher B
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575625/
https://ncbi.nlm.nih.gov/pubmed/18620607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2453
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