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High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

Self-reactive T cells with low signalling capacity through the T-cell receptor were recently observed in the SKG mouse model of rheumatoid arthritis (RA) and have been linked to a spontaneous mutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive...

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Detalhes bibliográficos
Main Authors: Thomas, Ranjeny, Turner, Malcolm, Cope, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575618/
https://ncbi.nlm.nih.gov/pubmed/18710589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2446
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