Laddar...

High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

Self-reactive T cells with low signalling capacity through the T-cell receptor were recently observed in the SKG mouse model of rheumatoid arthritis (RA) and have been linked to a spontaneous mutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Thomas, Ranjeny, Turner, Malcolm, Cope, Andrew P
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575618/
https://ncbi.nlm.nih.gov/pubmed/18710589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2446
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!