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High mobility group box-1 protein – one step closer to the clinic?

High mobility group box (HMGB)1, originally described as a nuclear protein that binds to and modifies DNA, is now regarded as a central mediator of inflammation by acting as a cytokine. HMGB1 is postulated to be particularly important as a late acting mediator of lethal septicaemia in mice. Furtherm...

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Hlavní autor: Mollnes, Tom Eirik
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575561/
https://ncbi.nlm.nih.gov/pubmed/18671827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc6944
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