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Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats

Substitutive cell therapy using fetal striatal grafts has demonstrated preliminary clinical success in patients with Huntington's disease, but the logistics required for accessing fetal cells preclude its extension to the relevant population of patients. Human embryonic stem (hES) cells theoret...

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Auteurs principaux: Aubry, Laetitia, Bugi, Aurore, Lefort, Nathalie, Rousseau, France, Peschanski, Marc, Perrier, Anselme L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575484/
https://ncbi.nlm.nih.gov/pubmed/18922775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808488105
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