Inhibitory Control Over Ca(2+) Sparks via Mechanosensitive Channels Is Disrupted in Dystrophin Deficient Muscle but Restored by Mini-Dystrophin Expression

BACKGROUND: In dystrophic skeletal muscle, osmotic stimuli somehow relieve inhibitory control of dihydropyridine receptors (DHPR) on spontaneous sarcoplasmic reticulum elementary Ca(2+) release events (ECRE) in high Ca(2+) external environments. Such ‘uncontrolled’ Ca(2+) sparks were suggested to ac...

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Detalhes bibliográficos
Main Authors: Teichmann, Martin D. H., Wegner, Frederic v., Fink, Rainer H. A., Chamberlain, Jeffrey S., Launikonis, Bradley S., Martinac, Boris, Friedrich, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575405/
https://ncbi.nlm.nih.gov/pubmed/18982068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003644
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