Integrin-mediated Protein Kinase A Activation at the Leading Edge of Migrating Cells

cAMP-dependent protein kinase A (PKA) is important in processes requiring localized cell protrusion, such as cell migration and axonal path finding. Here, we used a membrane-targeted PKA biosensor to reveal activation of PKA at the leading edge of migrating cells. Previous studies show that PKA acti...

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Hauptverfasser: Lim, Chinten J., Kain, Kristin H., Tkachenko, Eugene, Goldfinger, Lawrence E., Gutierrez, Edgar, Allen, Michael D., Groisman, Alex, Zhang, Jin, Ginsberg, Mark H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575143/
https://ncbi.nlm.nih.gov/pubmed/18784251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-06-0564
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