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Histoplasma capsulatum secreted γ-glutamyltransferase reduces iron by generating an efficient ferric reductant

The intracellular fungal pathogen Histoplasma capsulatum (Hc) resides in mammalian macrophages and causes respiratory and systemic disease. Iron limitation is an important host antimicrobial defense, and iron acquisition is critical for microbial pathogenesis. Hc displays several iron acquisition me...

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Detalhes bibliográficos
Main Authors: Zarnowski, Robert, Cooper, Kendal G., Brunold, Laura Schmitt, Calaycay, Jimmy, Woods, Jon P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574916/
https://ncbi.nlm.nih.gov/pubmed/18761625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06410.x
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