The basal level of intracellular calcium gates the activation of phosphoinositide 3-kinase - Akt signaling by brain-derived neurotrophic factor in cortical neurons

Brain derived neurotrophic factor (BDNF) mediates survival and neuroplasticity through the activation of phosphoinositide 3-kinase (PI3K)-Akt pathway. Although previous studies suggested the roles of MAPK, PLC-γ-mediated intra-cellular calcium ([Ca(2+)](i)) increase, and extra-cellular calcium influ...

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Hlavní autoři: Zheng, Fei, Soellner, Deborah, Nunez, Joseph, Wang, Hongbing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574892/
https://ncbi.nlm.nih.gov/pubmed/18485103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05478.x
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