Sickle Cell Trait is Associated with a Delayed Onset of Malaria: Implications for Time to Event Analysis in Clinical Studies of Malaria

BACKGROUND: The World Health Organization (WHO) recently recommended that the time to first malaria episode serve as the primary endpoint in phase III malaria vaccine trials—the first of which will be held in Africa. Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (Hb) S...

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Main Authors: Crompton, Peter D., Traore, Boubacar, Kayentao, Kassoum, Doumbo, Safiatou, Ongoiba, Aissata, Diakite, Seidina A.S., Krause, Michael A., Doumtabe, Didier, Kone, Younoussou, Weiss, Greta, Huang, Chiung-Yu, Doumbia, Seydou, Guindo, Aldiouma, Fairhurst, Rick M., Miller, Louis H., Pierce, Susan K., Doumbo, Ogobara K.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574881/
https://ncbi.nlm.nih.gov/pubmed/18752444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/592224
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