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Probability that a two-stage genome-wide association study will detect a disease-associated SNP and implications for multistage designs
Large two-stage genome-wide association studies (GWASs) have been shown to reduce required genotyping with little loss of power, compared to a one-stage design, provided a substantial fraction of cases and controls,π(sample), is included in stage 1. However, a number of recent GWASs have used π(samp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574571/ https://ncbi.nlm.nih.gov/pubmed/18652601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-1809.2008.00467.x |
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