Design of Amphiphilic Protein Maquettes: Controlling Assembly, Membrane Insertion, and Cofactor Interactions

We have designed polypeptides combining selected lipophilic (LP) and hydrophilic (HP) sequences that assemble into amphiphilic (AP) α-helical bundles to reproduce key structure characteristics and functional elements of natural membrane proteins. The principal AP maquette (AP1) developed here joins...

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Detalhes bibliográficos
Main Authors: Discher, Bohdana M., Noy, Dror, Strzalka, Joseph, Ye, Shixin, Moser, Christopher C., Lear, James D., Blasie, J. Kent, Dutton, P. Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574520/
https://ncbi.nlm.nih.gov/pubmed/16156646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050695m
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